Purpose: The effect of impaired oral functions is best described by the patient, and a shift toward a patient-oriented decision-making process in oral rehabilitation is evident. The Oral Health Impact Profile-49 (OHIP-49) questionnaire has been the most commonly used method to measure oral health-related quality of life (OHRQoL) in dentistry. An individualized method, the Schedule for the Evaluation of Individual Quality of Life-Direct Weighing (SEIQoL-DW), has proven to fulfill most of the criteria for a method to assist in the decision-making process. The purpose of this study was to compare the ability of the OHIP-49 questionnaire and the SEIQoL-DW method in measuring OHRQoL and generating useful information for decision making in oral rehabilitation. Materials and Methods: Sixty participants in need of oral rehabilitation were enrolled in the study. Patients received a clinical examination, were interviewed using the SEIQoL-DW, filled out the OHIP-49 questionnaire, and answered two global oral health-rating questions. Results: The SEIQoL-DW generated additional information compared to the OHIP-49. The information was more oral- and treatment-specific, including consultation issues and the patient-practitioner relationship. The overall SEIQoL-DW and OHIP-49 scores were significantly correlated. The OHIP-49 and SEIQoL-DW scores were related to oral health subjectively. Conclusions: The SEIQoL-DW method proved a useful aid in clinical decision making for oral rehabilitation. The SEIQoL-DW was more appropriate for generating information useful for decision making than measuring OHRQoL; the OHIP-49 was more appropriate for measuring OHRQoL than generating information.