The aim of this study was to investigate the marginal fit of posterior fixed partial dentures (FPDs) made with 2 computer-aided design/computer-assisted manufacture systems-Procera Bridge Zirconia (Nobel Biocare) and Lava AllCeramic System (3M ESPE)-and to analyze the differences between abutments and between buccal and lingual surfaces. Twenty standardized specimens were prepared to receive posterior 3-unit FPDs. FPDs were fabricated according to the manufacturer's instructions. A scanning microscope (JSM-6400, JEOL) with a magnification of 1,0003 was used for measurements. Three-way analysis of variance showed significant differences (P .001) in marginal adaptation between the ceramic groups. Procera Bridge Zirconia showed the lowest discrepancies (26 ± 19 µm). No significant differences were observed between abutments and surfaces, and no significant interaction was observed among the ceramic system, abutments, and surfaces. The accuracy of fit achieved by both zirconia systems was within the range of clinical acceptability, with Procera Bridge Zirconia showing the best marginal fit.