The aim was to evaluate the influence on the stress distribution patterns in and the magnitude of stresses on fixed partial dentures (FPDs) under different anatomic and design conditions. Three-dimensional finite element models of posterior 3-unit all-ceramic FPDs were created with and without periodontal ligaments, with different radii of curvature at the embrasure area, and in a curve shape with a periodontal ligament. The model with a periodontal ligament showed 40% higher stress values compared to the no-ligament model. A smaller radius of curvature resulted in 20% to 40% higher stress values. The curved model increased stress values at the distal connector by 65% compared to the straight model. Support by teeth, occlusal curvature, and a small radius of curvature at the embrasure area negatively affect stress distribution patterns in the connector area of all-ceramic FPDs.