Purpose: This study aimed to investigate the release of nickel, copper, zinc, cadmium, magnesium, and lead from prosthodontic base metal alloys into protein-containing biologic solutions. Materials and Methods: Dissolution experiments were conducted in either 3% Dulbecco's Modified Eagle Medium or 3% bovine serum albumin solutions for 7 weeks. Results: The protein-containing dissolution solutions and dissolution time did not have a significant effect on release of elements from the alloys (Kruskal-Wallis, P > .05). Conclusions: The amount of the released elements was well below the dietary intake levels of these elements. This study is important given the widespread use of the base metal alloys and the continuing public concerns/questions regarding the health benefits/risks associated with these materials.