Surface decontamination in the reconstructive therapy of peri-implantitis is of paramount importance

to achieve favorable outcomes. The objective of this single-center study derived from a large multicenter

clinical trial was to compare the electrolytic method (EM) used as an adjunct to mechanical

decontamination, to hydrogen peroxide (HP) also used as an adjunct to mechanical decontamination, in

the reconstructive therapy of peri-implantitis. At 12-month (T2) follow-up, 19 patients (Nimplants=

23) completed the study. None of the tested modalities demonstrated superiority in terms of the

assessed clinical parameters. Only mucosal recession showed higher stability in the EM group. Alike,

radiographic marginal bone level gain and defect angle changes at T2 did not differ between the

evaluated strategies. Notably, disease resolution was ∼16% higher in the EM; however, differences did

not reach statistical significance. Additionally, it was demonstrated that pocket depth and intra-bony

component depth at baseline were predictors of disease resolution. In conclusion, the EM combined

with mechanical instrumentation results in a safe and effective surface decontamination modality in the

reconstructive therapy of peri-implantitis. This strategy resulted in ∼91% disease resolution rate.