Purpose: To investigate the influence of a novel scanning strategy—using two new intraoral scanner devices with different operators—on the full-arch scanning accuracy for a dentate maxilla. Materials and Methods: Two scanning strategies, a test and a control strategy, were used to produce full-arch impressions of the dentate maxilla of a study patient. Two intraoral scanning (IOS) devices were used. Five expert operators performed a total of 40 scans. The scan time was recorded for each. A reference model was obtained from the patient’s maxillary arch with an analog impression. The model was later scanned with a high-precision laboratory scanner to create a digital reference model (DRM). The scanning accuracy was analyzed with 3D-analysis software using a root mean square (RMS) calculation method, and qualitative analysis was executed using machine learning software. Results: The mean RMS result for the test strategy was 82.8 ± 16 μm compared to 81.5 ± 16 μm for the control strategy. The mean RMS results were 84.7 ± 15 μm for Primescan (PS) and 79.6 ± 17 μm for 3Shape (3S). As such, the scanning strategies and IOS devices did not influence the scanning accuracy. Yet, a significant difference was found when the two strategies’ scanning times were compared (P = .001), as well as the IOS devices (P = .001). The operator was found to have no influence on the scanning strategy. Conclusions: The accuracy of digital impressions is not influenced by different strategies, devices, or operators, in contrast with the scanning time, which is influenced by both strategies and devices.