The technology of combined dentures brings often the need for joining dissimilar alloys. Purpose: The aim of the study was to provide information for successfully joining of used alloy combinations. Materials and methods: For experimental tests Ni-Cr and Co-Cr alloys plates were cast conventionally using an induction melting centrifugal casting machine. They were welded bilaterally with and without filler material, using a microplasma Welder. Welded specimens were analyzed macroscopically, microstructural and the microhardness were determined in the base metal (BM), welded metal (WM) and heat affected zone (HAZ). Results: Metallographic analyses and microhardness tests showed structural changes particularly in the HAZ, with precipitates of some compounds, which harden the respective area. At samples where the filling material was used, voids were present in the WM. Conclusion: The microstructure depends on the processing parameters and the composition of the filler material. Keywords: processing parametrs, dissimilar welding, dental alloys