Aim: Root canal treatment of a taurodont tooth is challenging because of the wide variations in the anatomy of the pulp chamber and root canal configurations. The nonsurgical root canal treatment of an unusual case of taurodontism in a maxillary central incisor is reported in this study. Methods: Clinical and radiographic examinations of a right maxillary central incisor revealed the presence of a sinus tract, a short root with apical displacement of the floor of the pulp chamber and two root canals. A large periradicular lesion was observed, and the diagnosis of asymptomatic suppurative apical periodontitis was made, and root canal treatment was carried out. The root canals were accessed, chemomechanically prepared and filled with a calcium hydroxide dressing. The dressing was replaced over a 6-month period. A significant reduction in periradicular radiolucency was observed, and obturation of the root canal system was undertaken using a warm compaction technique with gutta-percha and an epoxy resin-based sealer. Results: The tooth was asymptomatic and functional, and periapical repair was observed radiographically after an 18-month follow-up. Conclusion: Although taurodontism is an anomaly predominantly seen in multirooted teeth, this case report describes how a non-surgical root canal treatment of an unusual taurodont maxillary central incisor was performed. Keywords: morphologic change, nonsurgical endodontic treatment, pulp chamber, taurodontism