This study investigated the influence of internal surface treatment and margin location on the microleakage of 2 alumina-reinforced ceramic crown systems: In-Ceram (VITA Zahnfabrik) and Procera (Nobel Biocare). Full crowns were produced for each of the 2 systems (n = 24) in human premolars, with margins located in enamel and dentin, and luted with Single Bond and RelyX ARC (3M ESPE). Four internal ceramic treatments were tested: (1) aluminum oxide blasting (AO), (2) AO plus silane, (3) hydrofluoric acid etching (HF), and (4) HF plus silane. After thermal cycling, leakage was measured quantitatively. Statistical analysis (P .05) showed higher leakage in dentin margins compared to enamel. In enamel, Procera showed greater leakage compared to In-Ceram. Generally, lower microleakage was observed for the AO plus silane treatment.