Purpose: To evaluate the predictability of Straumann wide-neck dental implants (6.5-mm prosthetic neck with a 4.8-mm endosseous sandblasted, large-grit, acid-etched-surface body) used for molar replacement. Materials and Methods: Four hundred ninety-nine single-tooth implants were restored in molar sites in 410 patients (mean time of loading 23 months; range, 1 to 54 months) by 6 clinicians throughout the United States. Three hundred-fifty nine implants were placed in the mandible and 148 implants in the maxilla. Results: The overall cumulative survival rate was 98.4% for all sites (8 failures). Survival rates of 99.2% for mandibular molars (3 failures) and 96.6% for maxillary molars (5 failures) were achieved. Survival rate of implants placed in conjunction with the bone-added osteotome procedure in the maxillary molars was 89%, with 5 of 45 procedures leading to failure. Discussion: Minimal restorative problems were encountered. No cases of abutment loosening or fractures were observed for cemented restorations on solid abutments. Conclusion: The data suggest that the Straumann solid-screw, wide-neck implants can be a satisfactory choice for molar single-tooth replacement. Keywords: cemented implant crowns, implant survival, prosthetic complications, wide-diameter dental implants