Purpose: This investigation was conducted to obtain preliminary roughness data on a microtextured implant surface and to determine its ability to sustain a 1-stage surgical procedure and early full occlusal loading of single-tooth restorations in humans. Materials and Methods: Three-dimensional (3D) vertical scanning interferometry was conducted on samples of the test surface (MTX) and 2 control surfaces (Osseotite and sandblasted/acid-etched [SLA]). Test implants were also placed in vivo, restored with fully occluding single-tooth restorations (n = 27) after 2 months of nonsubmerged healing, and clinically monitored for 48 months of follow-up. Results: Microtexture was relatively uniform on the test surface and more random and irregular on the control surfaces. MTX and Osseotite were similar in some roughness parameters, but the MTX surface had a greater number of micropits that were spaced closer together (Stylus Y λq) and with higher slope values (Stylus Y Δq). Cumulative life table results were 100% for all MTX implants placed in maxillary and mandibular jaw locations, and no discernible marginal bone changes were observed. Overall implant success was 100% after 4 years of clinical functioning. Discussion: The findings of this study appear promising but should be considered preliminary, because of the limitations in the number of locations measured on each product sample and the small number of implants clinically studied. Conclusion: Within the scope of the present study, MTX implants exhibited a uniform micropitted surface, as well as 100% survival and 100% clinical success after nonsubmerged placement, early loading with single-tooth restorations at 2 months, and 48 months of clinical functioning. (More than 50 references.)