Purpose: The aim of this clinical study was to evaluate the postoperative hypersensitivity of Empress II inlays/onlays luted under clinical conditions with XP BOND in combination with SCA and Calibra cured in self-curing mode. Materials and Methods: Fifty-three restorations were placed in 38 patients in March and April 2006. No patient received more than two restorations. Luting procedures were performed following manufacturers' instructions. The restorations were evaluated after 2 weeks and 6 months for postoperative hypersensitivity, marginal discoloration, marginal integrity, secondary caries, maintenance of interproximal contact, and fracture. Results: At the 2-week recall, the postoperative hypersensitivity was reported in only 10 and after 6 months in only 3 patients. All other parameters showed alpha scores. Conclusion: All the evaluated restorations were in place and acceptable. The postoperative hypersensitivity recorded after using XP BOND and Calibra in self-curing mode was clinically acceptable. Keywords: ceramic crowns, self-curing, clinical trial, bonding