Purpose: To assess the clinical performance of CAD/CAM laminate veneers placed by a single operator and systematically evaluated for up to 10 years. Materials and Methods: A total of 197 laminate veneers fabricated using either feldspathic ceramics (VMII) or lithium disilicate ceramics (EmaxCAD) were followed up to 10 years in 32 patients. Technical, esthetic, and biologic findings of each restoration were evaluated using modified United States Public Health Service criteria. The survival and complication rates were assessed using Kaplan-Meier survival analysis and compared using log-rank test. Statistical significance was set at P < .05. Results: The estimated Kaplan-Meier survival rate was 91.9% after the mean observation period. According to the ceramic system used, the estimated Kaplan-Meier survival rate amounted to 92.7% for EmaxCAD and 89.1% for VMII. Survival rates were significantly affected by the location of veneer according to log-rank test (P < .05). A range of survival rates between 83.3% and 98.6% were observed based on the location of veneer. Conclusions: CAD/CAM laminate veneers milled from feldspathic or lithium disilicate ceramics have comparable long-term survival rates. Oral positioning affects the survival of veneers. Veneers of incisors have higher survival rates than the veneers of maxillary canines and premolars.