Purpose: To compare the clinical outcome of single, partial and full fixed implant-supported prostheses immediately loaded (within 48 h), early loaded at 6 weeks and conventionally loaded at 3 months (delayed loading). Materials and methods: Eighty-one patients (27 requiring single implants, 27 requiring partial fixed prostheses and 27 requiring total fixed cross-arch prostheses) were randomised in equal numbers in three private practices to immediate loading (27 patients), early loading (27 patients) and conventional loading (27 patients) according to a parallel group design with three arms. To be immediately or early loaded, implants had to be inserted with a torque superior to 40 Ncm. Implants were initially loaded with provisional prostheses and replaced after 4 months by definitive ones. Outcome measures were prosthesis and implant failures and complications. Results: No patient dropped out up to 4-months post-loading. No implant or prosthesis failed or any complications occurred. Conclusions: All loading strategies were highly successful and no differences could be observed for implant survival and complications when loading implants immediately, early or conventionally.