PMID- 30986287 OWN - Quintessence Publishing Company, Ltd. CI - Copyright Quintessence Publishing Company, Ltd. OCI - Copyright Quintessence Publishing Company, Ltd. TA - Int J Periodontics Restorative Dent JT - International Journal of Periodontics & Restorative Dentistry IS - 1945-3388 (Electronic) IS - 0198-7569 (Print) IP - 3 VI - 39 PST - ppublish DP - 2019 PG - 371-379 LA - en TI - Bone Tissue Responses to Zirconia Implants Modified by Biomimetic Coating Incorporated with BMP-2 LID - 10.11607/prd.3980 [doi] FAU - Teng, Fei AU - Teng F FAU - Zheng, Yuanna AU - Zheng Y FAU - Wu, Gang AU - Wu G FAU - Beekmans, Bart AU - Beekmans B FAU - Wismeijer, Daniel AU - Wismeijer D FAU - Lin, Xingnan AU - Lin X FAU - Liu, Yuelian AU - Liu Y CN - AB - This study aimed to histologically investigate the bone tissue response to zirconia implants functionalized with a biomimetic calcium phosphate (CaP) coating incorporated with bone morphogenetic protein-2 (BMP-2). Zirconia implants coated with biomimetic CaP were prepared with and without BMP-2. Untreated zirconia implants served as a control. These three groups of implants were placed randomly in the mandibles of six beagle dogs (n = 6). Three months later, samples were harvested for histomorphometric analysis. The present study showed that the application of a biomimetic CaP coating incorporated with BMP-2 enhanced the peri-implant osteogenesis for zirconia implants. AID - 854425